Sentence examples for mediating at least from inspiring English sources

CTGF is thought to act both as a profibrotic marker and as a downstream effector of TGFβ by mediating at least some of its profibrotic activities.

We demonstrate that manipulation of Fto expression in the arcuate nucleus bi-directionally influences acute food intake in rats, implicating the brain and specifically the ARC in mediating at least some of the effects of FTO on energy balance.

The DC matured in the presence of Vpr are defective in the production of IL-12 and eventually lose their ability to orchestrate productive T cell responses thus mediating, at least in part, the switch from Th1 to Th2 cytokine production which is a hallmark of progression to AIDS.

Increases in diacylglycerol seem to play an important role in mediating at least part of the downstream GPR40 signaling.

Our results certainly implicate NFκB in mediating at least part of the phenotype in NDRG1 overexpressing cells, given our compartment fractionation and ChIP data.

Flavonoid compounds have various biological activities, including anti-inflammatory and anti-cancer ones [ 21], and may be mediating, at least in part, the effects shown here.

Our findings suggest that TIG1-mediated growth suppression of colon cancer cells is mediated, at least in part, through GRK5.

Taken together, these results suggest that SFPS-mediated induction of cytokines and NO production in macrophages is mediated, at least in part, by TLRs/NF-κB signaling pathway.

TRiC binding to Stat3 was mediated, at least in part, by TRiC subunit CCT3.

This effect appears to be mediated, at least partially, by calcium antagonism.

These effects are mediated, at least in part, by curaxin-induced depletion or dissociation of CTCF from its binding sites.