Sentence examples for mediating apoptotic responses from inspiring English sources

Furthermore, MAPK signals are robustly activated in a variety of disease states and have been implicated in mediating apoptotic responses.

For example, Yue et al. [ 36] performed MALDI-MS/MS analysis of an interactome map and identified a network of 21 differentiated regulated core proteins which are responsible for mediating apoptotic response to Ganoderic acid D treatment in Hela cells.

The intrinsic pathway mediates apoptotic responses to stress signals such as drugs, DNA damage or growth factor deprivation and is initiated by mitochondrial damage.

ARB treatment attenuated GS, suppressed intra-renal oxidative stress, restored ER-associated adaptive/cytoprotective system, and prevented the ER stress mediated apoptotic response in this model.

Other reports have also suggested that statins mediate apoptotic response by activating Fas (cluster of differentiation 95-Apo1 -induced 95-Apo1 -induceding via their ability to disrupt cholesterol-enriched lipid rafts.

As such, a better comprehension of the role of specific organelles in mediating apoptotic photoinduced response provides a possibility to manipulate the cell death machinery.

TP73 is a member of the TP53 tumor suppressor gene family that has been found to be overexpressed in a variety of tumors and mediates apoptotic responses to genotoxic stress.

19, 23 JNK-dependent phosphorylation of Bim and Bmf was shown to mediate UV-mediated apoptotic response via releasing these proteins from dynein motor components.

The CHOP, JNK and Caspases are distal effectors of ER stress response that have been implicated in mediating apoptotic signals.

GADD45 gamma was preferentially induced in A431 cells in response to telomere inhibition and it induced the expression of GADD153, which mediates the apoptotic responses or growth arrest when GADD153 is knocked out.

To assess the importance of TOP2A in mediating bDMC apoptotic response, we knocked down TOP2A by transient RNAi.