Sentence examples for mediating apoptosis of from inspiring English sources

The efficacy of TRAIL in mediating apoptosis of MCF7 breast cancer cells was assessed using Ad5hTRAIL construct.

The important role of TNF α in the pathogenesis of HIV infection and its associated complications, particularly enhancing viral replication and mediating apoptosis of CD4T cells, has been studied extensively and recently reviewed elsewhere.

TRAIL is a member of the TNF superfamily that has been implicated in mediating apoptosis of CD4T cells in HIV infection through its interactions with its death-inducing receptors, DR4 and DR5, on infected and uninfected T cells.

The whole-transcriptome sequencing analysis uncovered enhanced expression of CASP3 and DIABLO, whereas XIAP was decreased in DMD iPSC-CMs (Fig. 3A,B), implying a possible role of mitochondria (Verhagen et al., 2000) in mediating apoptosis of DMD iPSC-CMs.

There are conflicting opinions about the role of tumour FasL in mediating apoptosis of immune cells and counterattacking the host's defence systems (Rivoltini et al, 1998; Chappell et al, 1999; Restifo and Rosenberg, 1999; O'Connell et al, 2001).

The results revealed that compound 3a induced cell cycle cessation at G2/M phase and accumulation of cells in pre-G1 phase and prevented its mitotic cycle, in addition to its activation of caspase-7 mediating apoptosis of MCF-7 cells.

The leukocyte specific protein 1 or LSP1 is a multi functional protein involved in such divers biological processes as the regulation of neutrophil motility, chemotaxis, adhesion and membrane immunoglobulin M (mIgM) mediated apoptosis of B-lymphocytes.

Acting as primary coordinators of the apoptotic processes, reactive oxygen species (ROS) generated by NTP can mediate apoptosis of mammalian cancer cells by mitochondrial dysfunction.

This suggests that in addition to the P2Y2-receptor triggered [Ca2+]i-increase other signalling pathways may mediate apoptosis of oesophageal cancer cells in response to ATP.

We refer to this region as Death Domain-1 (DD1) since it is necessary and sufficient to mediate apoptosis of breast cancer cells.

TNF-related apoptosis-inducing ligand (TRAIL) is a cell-death-inducing ligand that mediates apoptosis of target cells in mice through the engagement of its cellular receptor death receptor 5 (DR5) 28.