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Like its vertebrate counterparts, Zyx102 displays three carboxy-terminal LIM domains, a potential nuclear export signal, and three proline-rich motifs, one of which matches the consensus for mediating an interaction with Ena/VASP (Drosophila Enabled/Vasodilator-stimulated phosphoprotein) proteins.
Here we identify a novel domain in the PC-1 C-terminal tail, a polyproline motif mediating an interaction with Src homology domain 3 (SH3).
Since there is no interaction of the protein with PtdIns, we can conclude that the addition of the phosphate group to the lipid is important for mediating an interaction with JP2.
It is well-known that intermolecular magnetic interactions between [ReCl6]2− anions can be non-negligible because of the strong π spin delocalization from the ReIV ion onto the chlorine ions, mediating an interaction between spin densities on neighbouring molecules.
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The poly-lysine (pK) incorporated into pIX locales in AdLucIXpK has been shown to mediate Ad interaction with cellular heparan sulfate proteoglycans (HSPGs), resulting in CAR-independent virus-cell binding and transduction [13].
They are defined as 'a chemical that carries information that mediates an interaction among two individuals and results in an adaptive response in the receiver.
The TPR domain of CHIP is known to mediate an interaction with Hsp70 [43].
In addition to a BAG domain, BAG1 contains a ubiquitin-like domain which may mediate an interaction with the 26S proteasome [54].
The cytoplasmic C-terminus of PC-1 contains a coiled-coil domain that mediates an interaction with the PKD2 gene product, Polycystin-2 (PC-2).
The vertebrate and Drosophila NuRD complexes also contain the methyl-CpG-binding protein MBD2/3, which is proposed to mediate an interaction between NuRD and methylated DNA [17].
Here, we report that the C-terminus of PC-1 contains at least one polyproline domain that is able to mediate an interaction with Src-homology 3 domains (SH3).
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CEO of Professional Science Editing for Scientists @ prosciediting.com