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Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury.
BDNF signaling plays major roles in mediating adaptive responses of the nervous, cardiovascular, and energy-regulating organ systems in response to exercise and energy restriction.
These extracellular vesicles are not simply 'garbage bags' or a route for exclusion of surplus molecules but active effectors in mediating adaptive responses in targeting cells [ 22].
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The phytohormone ABA is involved in various aspects of plant growth and development, and one of its major roles is to mediate adaptive responses to various environmental stresses (Hossain et al. [2010b]).
Two-component systems are known to mediate adaptive responses to various environmental signals [32].
In E. tarda, TCSs may mediate adaptive responses to a broad range of environmental stimuli, including phosphate/Mg2+ limitation (Pho), anaerobic condition (Cit and Arc), heavy metal overload (Cus), osmosis change (EnvZ/OmpR), and motility/chemotaxis (Che), etc.
In the normal condition, the mtROS participate in critical signaling pathways to mediate adaptive responses and regulate diverse biological functions.
HIF-1α is a transcriptional activator that mediates adaptive responses to hypoxia through the induction of a number of growth factors and cytokines [ 2, 9].
Acriflavine inhibits dimerization of HIF-1, a transcription factor that mediates adaptive responses to hypoxia and plays a critical role in cancer progression [ 7].
It is known that ABA mediates adaptive responses to abiotic and biotic stresses in vegetative tissues [ 59, 60], although the role of ABA in UV-B-induced responses has just begun to be elucidated [ 16, 17, 61].
Auxin interferes with JA and SA signaling, and the negative regulation of auxin is supposed to mediate adaptive response to biotic stress [ 84, 85].
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