Sentence examples for mediating activity of from inspiring English sources

Thus for a CRM found by the ModuleFinder algorithm [ 13], just as for the CRMs identified through our own TFBS co-occurrence based search, TFBSs that formed the basis of a successful prediction may not play a large role in mediating activity of the discovered CRM.

Furthermore, C5a mediates activity of immune complexes by regulating expression of FcγRs [ 30, 39].

Identification of an important regulator that can mediate activity of the NF- κB pathway and subsequently regulate MSC therapeutic efficacy for MI is vital.

Here we identify the putative transcription factor binding sites that mediate activity of these regulatory regions and use the information to study the regulation of the human APP locus.

This is consistent with other studies illustrating that multiple proteins that are involved in mechanotransduction become extended in response to mechanical force thus revealing cryptic interaction sites that mediate activity of the proteins.

IL-23 also mediates activities independent of IL-17.

IL-4Rα-mediated signalling also plays a role in the host antitumour immune response mediating immunosuppressive activity of tumour-induced myeloid-derived suppressor cells (MDSCs) (16).

The role protein-protein interactions in mediating the activity of the individual domains will also be discussed.

Although we did not observe a significant correlation between soluble inhibitors of inflammatory cytokines in APS and WOMAC pain scores, they still may have played an underlying role in mediating the activity of APS.

USF1/2 has been shown to play a critical role in mediating barrier activity of the chicken β globin gene, recruiting histone modifying enzymes [31], [32].

RalA regulates actin cytoskeleton organization by mediating the activity of downstream factor Rho/CDC42.