This protein mediates the export of CQ from the parasite digestive vacuole (DV) [ 6- 8], its presumed site of action [ 9].
Poulsen, H., Nilsson, J., Damgaard, C.K., Egebjerg, J. & Kjems, J. CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain.
The two major renal transporter proteins identified to date are the high affinity transporter URAT1 (SLC22A12) that mediates uptake of urate from the urine into the renal proximal tubular cell, and GLUT9 (SLC2A9/URATv1) which is a voltage-sensitive uniporter that mediates the export of UA from the proximal tubular cell into the circulation[118, 119].
It is know that COPII mediates the export of cargo from the ER.
The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP.
Tat and Rev travel to the nucleus where Tat activates transcription and Rev mediates the export of mRNAs in the late phase.
Although clathrin-coated vesicles mediate the export of mannose 6-phosphate receptors from the TGN, nothing is known about the transport vesicles used to carry these receptors back to the TGN.
Cargo proteins exposing a NES are usually recognized and bound by CRM1, mediating the export towards the cytoplasm of cellular and viral proteins as well as ribonucleoproteins [12], [13].
Rev-RRE interactions regulate viral gene expression and genomic replication by mediating the export of incompletely spliced or unspliced lentiviral mRNAs from the nucleus to the cytoplasm of infected host cells [7], [9].
This export is mediated by a host-targeting (HT) signal present on a "secretome" of hundreds of parasite proteins engaged in remodeling the erythrocyte.
