It mediates the differentiation of B-cells and enhances immunoglobulin secretion [ 12, 13].
16 IL-12 or IL-23 mediates the differentiation of these cells into Th1 or Th17, respectively.
IL-12 release is a functional characteristic of DC maturation and also crucial for mature DCs to mediate Th1 differentiation so as to enhance immune responses.
Moreover, concomitant down-regulation of TGF-β3 expression appears to be strictly correlated with transformation of QNR cells and partially mediate the differentiation block.
PGE2 can also mediate Th17 differentiation.
Specific signals and cytokines mediate the differentiation of Tregs and Th17 cells [ 41, 42].
This is in agreement with a previous report that CD44 mediates cell differentiation [58].
The ERK pathway mediates proliferation, differentiation, and plasticity of neurons in the central nervous system (Thomas and Huganir 2004).
The FRUITFULL (FUL) gene mediates cell differentiation during A. thaliana fruit development [ 31].
It is in the central of a molecular metabolic network that mediates cell differentiation and proliferation.
