Several members of the ADAM family of proteases are able to mediate this cleavage, but in neurons this function is likely to be exerted by the constitutively active ADAM10 protease [ 5].
In the absence of MASP-1 other enzymes, e.g. kallikrein and plasmin [ 38], mediate this cleavage, enabling the production of some FD and preserving some degree of AP activation.
In this study, we show that PS/γ-secretase mediates the cleavage of neurexins at synapses.
OMA1, a metallopeptidase of the inner mitochondrial membrane, mediates the cleavage of OPA1 in the absence of AFG3L2 (29).
This cleavage mediates disassembly of the cell into the typical apoptotic morphological changes, such as cell shrinkage, chromatin condensation, membrane blebbing, and DNA fragmentation [ 5].
In particular, caspase-7 was reported to mediate the cleavage of RTN-4B.
This may establish an autocrine loop: both MMP-2 and MMP-9 can mediate the cleavage of latent TGF-β complexes [ 28].
The presence of HvPHO2-associated sRNAs in P-deficient barley could substitute for miR399 in mediating the cleavage of HvPHO2.
As mentioned previously, caspases mediate the cleavage of Livin into a truncated form, tLivin, that is paradoxically a proapoptotic protein.
To test whether the identified miRNAs could mediate the cleavage of the predicted target mRNAs, a 5' RACE experiment was performed.
