Sentence examples for mediates the suppressive from inspiring English sources

In conclusion, we report for the first time the existence of a miRNA-regulated mechanism in human islet cells that mediates the suppressive effects of high glucose on insulin biosynthesis.

These data suggest that Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression.

Under ordinary conditions, STAT3 mediates the suppressive effect of IL6 on hepatic glucose production [ 32].

These data corroborate the ChIP data, suggesting that Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression, likely by competing with endogenous Sp1.

Together, these data indicate that Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression, likely through displacement of Sp1.

These data suggest that Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression through a mechanism involving displacement of prebound Sp1.

Ca2+ is an essential component for efficient elaboration of LPS- and LTA-mediated cytokine response but plays a differential role in mediating the suppressive effects of low pH stress.

These data, those of previous studies, and recent preliminary findings support involvement of dopamine D2, but not D1 or D3 receptors in mediating the suppressive effect of TA-0910 on alcohol intake of P rats.

Many studies suggest the importance of regulatory cytokines IL-10 and TGF-β in mediating the suppressive activity of Tregs [13].

Initial cell seeding density may be a critical factor in mediating the suppressive effects of CFTR on inflammation as only at a certain density (1×105 cells/well) did we observe the reduction in NF-κB activity.

The EP2 receptor was further implicated in mediating the suppressive effects of PGE2, as siRNA directed against Ptger2, but not scrambled or Ptger4 siRNA, prevented PGE2-induced decreases in Sost.