Sentence examples for mediates the secretion from inspiring English sources

ABC subfamily C member 2 (Abcc2) mediates the secretion of amphiphilic glutathione, glucuronide, and sulfate conjugates into bile.

Mitochondrial DNA also plays a key role in the activation of the NLRP3 inflammasome and mediates the secretion of IL-1β and IL-18 (Yu and Bennett, 2014).

Similarly, mtDNA also plays a key role in the activation of the NLRP3 inflammasome and mediates the secretion of IL-1β and IL-18, which might be associated with the induction of inflammatory disease.

We have so far demonstrated that integrin α3β1 mediates the secretion of IL-6 in response to the synthetic TLR2/1 ligand, Pam3CSK4, by regulating endocytosis of the ligand and facilitating its recognition by TLR2/1 from within endosomal compartments.

Unexpectedly, we recently found that autophagy, in addition to its degradative function, also mediates the secretion of Aβ.

This channel mediates the secretion of four exotoxins, namely ExoS, ExoT, ExoU and ExoY [ 2, 8, 11, 12].

Interestingly, expression of neither Cdc42V12 nor Rac1V12 resulted in increased levels of secreted uPA protein, indicating that although their activities are required to mediate the secretion of uPA in RasV12-transformed PH3MT cells, their activation alone is not sufficient to induce similar increases in expression.

Its ability to liberate numerous intracellular signaling proteins from the membrane and also mediate the secretion of amyloid-β protein (Aβ) has made modulation of γ-secretase activity a therapeutic goal for cancer and Alzheimer disease.

The expression vectors were designed to allow the rapid directional insertion of DNA encoding other immunogenic peptides to mediate the secretion of agglutinating scFv and full-length mAb reagents from transfected mammalian cells.

For example, in Alzheimer's disease, it is crucial in mediating the secretion of interleukin-1β following beta-amyloid stimulation [2].

ILDR1 was recently reported to be a lipoprotein receptor mediating the secretion of the fat-stimulated cholecystokinin (CCK) hormone in the small intestine, while ILDR1 in EpH4 mouse mammary epithelial cells in vitro was shown to recruit tricellulin to tTJs.