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These results suggest that Eph receptor signalling mediates the repression of spine proliferation induced by climbing fibre activity in Purkinje cell proximal dendrites.
Our findings in hepatocytes reveal a novel mechanism for the development of insulin resistance by providing the first direct evidence that miR-126 mediates the repression of IRS-1 expression in mitochondrial dysfunction.
Recent studies have also shown that CLF, an Arabidopsis homolog of E z), directly mediates the repression of AGAMOUS (AG) via H3K27 trimethylation and thus controls floral organogenesis [47], [48].
In particular, each mediates the repression of the same subset of outer membrane proteins (Guillier and Gottesman 2008).
Mechanistically, we demonstrate that miR-142-3p miR-142-3p miR-142-3pon of an interconnected set of actin cytoskeleton regulators.
It contains a fragment that mediates the repression of its own repression suggesting a complex regulation scheme.
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Coupled with biochemical data, these studies indicate that EZH2α and EZH2β are capable of forming distinct repressive complexes that mediate the repression of unique gene networks within a wide variety of biological processes already characterized for PRC2, including proliferation, migration and differentiation, among others [ 42].
In addition, investigations on the molecular function of Prdm14 have demonstrated that the factor interacts with the Polycomb Repressive Complex 2 (PRC2) to mediate the repression of diverse sets of genes via binding to H3K27me3, thereby ensuring a naïve ESC state.
We show here that EZH2 can also mediate the repression of estrogen-dependent transcription, and that moreover, the ability of both REA and EZH2 to repress estrogen-dependent transcription are mutually dependent.
The metabolic fate of this free iron is uncertain, but our results suggest that it can not mediate the repression of the Fur regulon under oxidative stress.
To identify the domains of Sox17 that mediate the repression of Smad3 transcriptional activity, reporter assays were performed using the Sox17 deletions and point mutant.
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