Based on existing evidence, it is also conceivable that membrane-anchored APP and secreted APP fragments share equal relevance in mediating the diverse physiologic roles of APP.
TNF binding to cell surface receptors mediates its physiologic actions, although the exact mechanism of TNF action is unknown.
If disease leads to a decrease of CO, the physiologic reaction of the body, mediated by baroreceptors, is to restore the likewise decreased arterial pressure to maintain cerebral perfusion pressure [67].
The physiologic response to stress is mediated by the hypothalamic-pituitary-adrenal axis (HPAA).
If disease leads to a decrease of CO, the physiologic reaction of the body, mediated by baroreceptors, is to restore the likewise decreased arterial pressure to maintain cerebral perfusion pressure [ 67].
Measurement of psychosocial stress differs from chemical pollution exposure assessment, because the physiologic impact of non-chemical stressors is mediated through individual perception [ 15].
They also noted linear low-dose extrapolation, a typical risk assessment operation with substances such as carcinogens, may be inappropriate and results in underestimated risk above the physiologic zone where estrogen activity is receptor mediated.
The glucocorticoid receptor is a ubiquitously expressed intracellular, ligand-dependent transcription factor, which mediates the action of glucocorticoids and influences physiologic functions essential for life.
Within the physiologic range, AVP promoted antinatriuresis in the distal nephron, mediated by V2R.
The discovery that cytotoxic T-lymphocyte-associated protein 4 (CTLA4)- and programmed cell death protein 1 (PD-1 -dependent PD-1 -dependentide the basis for the PD-1 -dependentipheral imechanismsal tolerance suprovide the rationale that basising the inhibitory signals mediated by CTLA-4 or PD-1 would promote activation ofor cells thet can recognize tumor antigens and induce anti-tumor resphysiologic
