Sentence examples for mediates the phosphorylation from inspiring English sources

Briefly, upon activation, Erk1/2 mediates the phosphorylation of the C-terminal kinase [ 3], which in turn auto-phosphorylates a serine residue in the linker region [ 3, 4] allowing the recruitment of PDK1 which, by phosphorylating the N-terminal kinase, leads to the activation of Rsk1, 2 and 3 [ 5, 6].

Here, we show that XDsh mediates the phosphorylation of XDpr1a by CKIδ.

mTORC1 signaling also mediates the phosphorylation of multiple residues on 4E-BP1, including Thr37/46 and Ser65.

The Cdk7 also mediates the phosphorylation of the activation segment of cyclin-dependent kinases (Cdks), e.g., Cdk2 [24].

First, in mammalian cells, RACK1 serves as a scaffold that mediates the phosphorylation and activation of the MAPK JNK by PKCβII [42].

However, a recent report revealed that JNK2 interacts with β-catenin and mediates the phosphorylation of β-catenin by Rac1, which is critical for the nuclear accumulation of β-catenin in response to Wnt signaling [6].

Akt1 mediated the phosphorylation of Bad at serine 136, which increased the interaction of serine 136-phosphorylated Bad with 14-3-3 14-3-3 14-3-3

(PMID 17555943) Akt1 mediated the phosphorylation of Bad at serine 136, which increased the interaction of serine 136-phosphorylated Bad with 14-3-3 14-3-3 14-3-3

Given the recent evidence that Brk phosphorylates STAT3 [ 1], we investigated whether this kinase could also mediate the phosphorylation of the related STAT5a and STAT5b proteins.

It indicated that mTOR might also mediate the phosphorylation of STAT3 at Tyr705, not only at Ser727.

ILK1 can also mediate the phosphorylation of a variety of intracellular substrates, particularly protein kinase B/Akt on serine-473 [20].