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How CXCR7 mediates the multiple functions has remained a mystery.
TrkA specifically mediates the multiple effects of the nerve growth factor (NGF) signaling through receptor autophosphorylation and downstream induction of the mitogen-activated protein kinase (MAPK) and protein kinase B (PKB/AKT) pathways [ 1].
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We have investigated the potential role of Wnt7b in mediating the multiple functions of Ihh signaling during endochondral bone development.
miR-23b-3p was downregulated in human colon cancer, which regulates FZD7 or MAP3k1 to mediate the multiple steps of metastasis in vivo.
If there is a creative class, in Richard Florida's phrase, there is also emerging what might be called a fusion class: people positioned to mediate among the multiple societies that claim them.
The stability of short animal toxins is often mediated by the multiple disulfide bridges of paired cysteines.
Therefore, it is necessary to apply a multiple target-based approach to elucidate the molecular mechanisms mediated by the multiple components of SST.
Identification of ninety-one insertion sequence (IS) elements representing twelve different IS families is consistent with the dynamic genome rearrangements observed, mediated by the multiple IS elements [ 3].
To differentiate whether the pathogenic effects were mediated by the multiple IFNα subtypes and/or the single IFNβ, we created congenic NZB mice lacking Ifnb and found that disease severity was unaltered, strongly implicating IFNα subtypes as the principal effectors.
Pigmentation penetrance was influenced by still another sex-linked gene, and Asher and colleagues hypothesized (Asher et al. 1996, p. 296) that all of these interactions are mediated via the multiple genes' actions on neural crest cells.
This family of transcriptional regulators mediates the response to multiple environmental stresses and the resistance to multiple antibiotics.
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