Sentence examples for mediates the integration from inspiring English sources

The integrase Int of SRL PAI mediates the integration adjacent to one or both identical paralogous tRNA genes serX and serW [22], [27].

Since the substitution from Asp 64 to Glu suppresses IN catalytic activity, the IN-EGFP fusion protein provided in trans exclusively mediates the integration of the recombinant HIV-1 fluorescent virions.

Furthermore, the phiC31 integrase recognizes native sequences in human and mouse genomes that possess partial sequence identity to attP, called pseudo attP sites, and mediates the integration of plasmids bearing an attB site into such pseudo attP sequences [6], [7].

In gene transfer applications, the PhiC31 integrase mediates the integration of plasmids bearing an attB site into sequences with partial sequence identity to attP (pseudo- attP sites).

Pseudogenes are hypothesized to arise by gene duplication, including retrotransposition during which a retrotransposase mediates the integration a transcript into the genome [ 4] (see Additional file 1).

miR-132 mediates the integration of adult-born neurons in dentate gyrus [ 24], the arborization of new neurons in the hippocampus [ 23], and radial migration of neurons via expression of FOXP2 [ 72].

It does not mediate the integration of the chimeric protein into the nuclear membrane in cultured cells, indicating that the lamin tail alone is not sufficient to direct the integration of a protein into the lamina in vivo.

Current evidence shows that autophagy is required for ER stress-associated apoptosis and mitochondrial turnover, thus may mediate the integration of the insulin/IGF-1 and mTOR signaling pathways with other cellular machineries in regulating longevity (Meijer and Codogno, 2009; Vellai, 2009).

Alignment of the amino acid sequences of EGF-like repeats 1 and 2 of Lrp5 and Lrp6 showed this region to be highly conserved in Lrp4 (Figure 1A), raising the possibility that Lrp4 might also interact with Wise and thereby mediate the integration of Wnt and Bmp signals during morphogenesis.

The RVE (integrase core) domain is associated with viral proteins that mediate the integration of a DNA copy of the viral genome into the host chromosome.

Integrases are able to mediate the integration reaction to generate the prophage but require a second phage-encoded protein, the recombinational directionality factor, or RDF to activate excision.