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Itoh, K. et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
Itoh, K. et al. An Nrf2/small Maf heterodimer mediates the induction of Phase II detoxifying enzyme genes through antioxidant response elements.
The uPA promoter contains an NF-kappaB binding site that directly mediates the induction of uPA expression by RelA.
It has been previously proposed that FGFR4 mediates the induction of hepatocyte proliferation by FGF19 [16] (French, D.M., in preparation).
In this case, Egr1 mediates the induction of p35 activating Cdk5, which is necessary for neurite-like outgrowth.
Protein kinase A, activated by elevated intracellular cAMP levels, phosphorylates downstream substrates and mediates the induction of genes required for aggregation and post-aggregation development.
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Phytochrome- and cryptochrome-mediated light signals mediate the induction of CCA1, LHY, and PRR9 genes [ 8, 16, 17].
Phosphorylation is known to mediate the induction of CRM1-dependent nuclear export of a variety of proteins ranging from transcription factors to protein kinases27,28,29,30.
α1B adrenoceptors in rat paraventricular nucleus overlap with, but do not mediate, the induction of c-fos expression by osmotic or restraint stress.
To test if the p53 3′UTR could mediate the induction of p53 upon treatment with etoposide we tested the response of the 3′UTR reporter in HEK293 cells and found etoposide significantly induced the expression of the reporter (Fig. 6e) without affecting mRNA abundance when compared to a control reporter lacking the p53 3′UTR (Supplementary Fig. 5G).
In this regard, PACAP/PAC1 signaling is critically required in the hypothalamus to mediate the induction of the hypothalamic-pituitary adrenal axis and likely plays a role in other areas of the CNS that mediate responses to emotional and other types of stress, such as the amygdala, bed nucleus of the stria terminalis, and locus coeruleus (reviewed in [64]).
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