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Sepsis is an infectious process induced generalized inflammatory response that mediates the excessive production of cytokines.
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The present study shows that the cytotoxic effect and induction of apoptosis by Fe-SP is predominantly mediated by the excessive generation of ROS in cell lines derived from NB or OC.
This activation is mediated via the excessive release of microparticles by STB, and are hence, termed STBM [67].
44 Angioedema attacks caused by C1-INH deficiency are mediated by the excessive release of vasoactive bradykinin.
Is the excess excessive?
Chronic low-grade inflammation in the expanding white adipose tissue (WAT) may mediate the association between excessive body fat accumulation and inflammatory diseases.
On the other hand, previous studies indicate that hyperglycemia induces excessive generation of superoxide and other reactive oxygen species (ROS) in several tissues, including the vascular endothelium, the retina and kidneys [ 17- 19] and that excessive ROS generation mediates the long term complications of diabetes in these organs.
Our observation that ROS play a role in producing diaphragm weakness during hyperglycemia is consistent with several previous reports indicating that excessive ROS generation mediates the development of diaphragm dysfunction in a variety of animal models of disease including congestive heart failure, mechanical ventilation-induced inactivity, sepsis, and during fatigue [ 23, 25, 50, 51].
We conclude that the excessive spindle movements of csnk-1 RNAi) csnk-1 RNAi membryos by Gα/GPR-1/2/LIN-5 areivity.
A study among 1035 mother-infant pairs showed that placental weight partially mediates the effect of maternal prepregnancy obesity and excessive gestational weight gain on birth weight [ 49].
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