Sentence examples for mediates the enhanced from inspiring English sources

Interestingly, exposing endothelial cells to high glucose was accompanied by a rapid increase in extracellular ATP [36] which apparently mediates the enhanced secretion of heparanase by glucose [36].

A bilateral pair of dopaminergic neurons in the fly brain mediates the enhanced locomotor activity induced by ethanol exposure, and promotes locomotion when directly activated.

Site directed mutagenesis, biochemical and structural analyses of the LukS-PV signal peptide indicate that this peptide is present at the S. aureus surface, binds to HS in solid phase assay, and mediates the enhanced S. aureus matrix component adhesion.

We attempted to understand the mechanism that mediates the enhanced cytotoxicty of the combination of SAHA and ML-60218 by examining their effects on tRNA levels.

The Rho/ROCK signaling pathway controls phosphorylation of the myosin light chain and mediates the enhanced acto-myosin contractility that is a critical feature of amoeboid cells [ 10, 11, 14].

Phosphorylated Chk1 was significantly reduced in the Rif1 knockdown Smad3−/− ESCs compared with the control knockdown Smad3−/− ESCs (Supplementary Figure S5B), suggesting that upregulation of Rif1 in Smad3−/− ESCs mediates the enhanced DNA damage response after UV irradiation.

In cultured cell lines, several amino acid-responsive genes such as ASNS (Asparagine synthetase) [6], [7], [8] and CHOP (C/EBP homologous protein) [9], [10], [11] have been reported to contain AAREs (Amino Acid Response Elements) that mediate the enhanced transcription and function as enhancer elements [10].

We herein report, for the first time, on a dual-targeting strategy for mediating the enhanced targeting activity of NPs to adipose endothelial cells in diet-induced obesity (DIO).

Further comparison between systemic RASSF1A KO mice and cardiac-specific RASSF1A CKO mice revealed a paracrine mechanism involving TNF-α secretion by cardiac fibroblasts that mediated the enhanced growth and fibrosis observed in RASSF1A KO hearts [137].

We previously indicated that the enhanced activation of Akt and JNK mediated the enhanced production of MIP-1α [11].

All these results suggested that the activated PKCδ mediated the enhanced ubiquitination of C/EBPα protein under NSC606985 treatment.