Sentence examples for mediates the downstream from inspiring English sources

Caspase-9 then mediates the downstream apoptotic factor activation, such as caspase-3.

Syk is the common signaling pathway of many receptors and also is the key kinase which mediates the downstream cell signaling [ 11].

DARPP-32 mediates the downstream effects of dopamine receptor activation, and thus plays an important role in the modulation of DA-related processes which are abnormal in individuals with autism.

We also showed that miR-27a inhibitors showed no effect on cell proliferation inhibition caused by EGFR knock down, indicating that EGFR mediates the downstream effect of miR-27a on cell proliferation.

On activation of the canonical Wnt pathway, β-catenin binds to the TCF/LEF (T-cell factor/lymphoid enhancer-binding factor) transcription factors and mediates the downstream target genes' expression.

CB2R belongs to the G-Protein Coupled Receptor (GPCR) superfamily and mediates the downstream effects of endogenous secreted cannabinoid receptor ligands (endocannabinoids) such as anandamide and 2-arachidonoylglycerol (2-AG).

Despite the importance of immune receptors to plant survival, few components that mediate the downstream signaling cascade have yet been characterized.

Because the XIK1 shares structural similarity with the LRR-RLK XA21, such as the extracellular LRR domain, a transmembrane domain that is required for the plasmembrane-localization of RLK proteins, and the intercellular active kinase domain, we suggest that XIK1 might work as a co-receptor of XA21 for PAMPs recognition and mediate the downstream signaling.

The PAK is another effector of Rac1 which works to mediate the downstream signaling of Rac1.

This finding implies that signaling nodes at PI3K-Akt is important for zebrafish hematopoiesis and angiogenesis, and might be involved in mediating the downstream signals of K-ras.

Also, the potent anti-tumor or anti-viral activity of NKT cells may be most beneficial under activation conditions that preferentially favor the development of either NKT1 or CD4− NKT cells, which can potently mediate the downstream activation of NK cells and CD8+ cytotoxic T lymphocytes, further amplifying anti-tumor or viral activity.