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Moreover, we observed aggressive behaviour that could be linked to altered expression of neuroligin-2, a membrane-bound cell adhesion protein that mediates synaptogenesis of mainly inhibitory synapses.
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Expression of these components in adult neurons demonstrated that Pi3 kinase-mediated synaptogenesis was age-independent, and therefore not a developmentally restricted phenomenon.
Most neurons form synapses exclusively with other neurons, but little is known about the molecular mechanisms mediating synaptogenesis in the central nervous system.
Further study showed that NT-3/TrkC interactions activated the PI3K/AKT/mTOR pathway and PI3K/AKT/CREB pathway affecting synaptogenesis of NSC-derived neurons.
CHL1, another member of the L1 subfamily, has a reported involvement in synaptogenesis of inhibitory interneurons, although it functions differently from L1.
Eight weeks after transplantation, the neural network created a favorable microenvironment for axonal regeneration and for survival and synaptogenesis of NSC-derived neurons.
Therefore, our results suggest that TSP-1 secreted by BMSCs plays a key role during synaptogenesis of RGCs in vitro.
We examined the role of LIS1 in synaptogenesis of post-migrational neurons and social behaviour in mice.
This time corresponds to the postnatal growth surge in rodents, which includes apoptosis, migration, and synaptogenesis of the brain tissue.
Furthermore, the results are consistent with the fact that IGF2R is the receptor that mediates the effect of IGF2 on synaptogenesis (Schmeisser et al, 2012) and memory formation (Chen et al, 2011).
This strongly suggests that Notch-Delta signaling plays a role in synaptogenesis, independent of its role in neurogenesis.
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