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GNAQ encodes for alpha subunit of q class of heterotrimeric GTP binding protein (Gq) that mediates signals between G-protein-coupled receptors (GPCRs) and stimulates all four isoforms of β phospholipase C (PLCβ) that catalyzes the hydrolysis of phosphatidylinositol biphosphate (PIP2).
This DGC stabilizes the sarcolemma and mediates signals between the cytoskeleton, membrane and extracellular matrix.
This protein complex mediates signals between enhancer-bound factors (activators) and the core transcriptional machinery.
For example, CasL, which mediates signals between integrin and possibly vimentin [ 96], and talin 1, which links integrin to actin [ 97], increased significantly.
Our results point toward the existence of an as yet unknown factor/mechanism, which mediates signals between kidney and bone, and which is involved in the very rapid regulation of plasma Ca2+.
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It has been shown that IRAK-4 mediates signaling between MyD88 and TRAF6 thereby providing an essential component in promoting downstream signals.
Functional dystrophin is localised to the inner face of the sarcolemma and binds to cytoskeletal F-actin and transmembrane beta-dystroglycan as part of multiprotein complex that mediates signalling between the cytoskeleton and the extracellular matrix.
Myelin proteins also appear to mediate signals between the myelin-forming cell and the axon [41].
We therefore used our differential gene expression profiling data to obtain insights into the ligand-receptor interactions that may mediate signals between the UGE and UGM in the prostate stem cell niche.
Much is still unknown, including which proteins mediate signals between the odontoblasts and nerves and whether cilium acts as a signal integrator.
Notch (receptor) in the SMCs and Jagged or Delta (ligands) in the endothelium are membrane bound proteins, mediating signals between cells in contact.
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