Sentence examples for mediates regression of from inspiring English sources

FOXO1 also mediates regression of cardiac hypertrophy by affecting autophagy [ 79].

Studies in animals have shown that TRAIL mediates regression of cancer xenografts without affecting normal tissues, and human phase I studies have demonstrated that TRAIL agonists are safe [ 3, 6].

Previous work has shown that CD8+ T cells are responsible for rejection of E.G7-OVA tumours and that administration of an anti-CD4 monoclonal antibody, that mediates regression of established E.G7-OVA tumours, leads to increased infiltration of CD8+ cells (Vasovic et al, 1997; Dyall et al, 1999).

Several studies have described a unique population of macrophages with properties of both inflammatory (M1) and tissue remodeling/fibrotic (M2) macrophages, termed scar-associated macrophages, arising from recruited Ly6Chi monocytes expressing high levels of MMP13 that mediate regression of liver fibrosis in animal models [86,131-136].

The role of naturally occurring cytotoxic T cells (CTLs) in mediating regression of HPV-related disease has not been proven.

IL10 is over expressed in breast tumours [ 16] and exogenous administration can mediate regression of tumour growth and breast cancer metastases in mice models [ 17].

These cells could be converted into effector cells by in vitro expansion with anti-CD3mAB and IL-2 and were capable of mediating regression of established metastases following adoptive transfer (Yoshizawa et al, 1991).

AMH mediates the regression of Müllerian ducts in the developing male fetus.

Administration of ex vivo cultured, naturally occurring tumor-infiltrating lymphocytes (TILs) has been shown to mediate durable regression of melanoma tumors.

Mmp13 has been shown to be expressed by macrophages in murine livers where it is involved in mediating the regression of hepatic fibrosis [45] and MMP-13 activity against fibrinogen has been shown in vitro [46].

Autophagy may also mediate the regression of cardiac hypertrophy [ 77].