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The reaction of NO with superoxide may lead to an increase in ONOO−, which mediates nitration of tyrosine residues in certain enzymes, including SODs.
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The ferrocene moiety of conjugate 2 displayed a strong inhibitory activity of peroxynitrite-mediated nitration of the neighboring tyrosine.
Prior to leukocyte infiltration during early EAU, selective peroxynitrite-mediated nitration of photoreceptor mitochondrial proteins occurs [17].
Taken together these data indicate that ONOO− mediated tyrosine nitration of IRS-1 largely accounts for iNOS-induced IR in skeletal muscle cells.
Insect peroxidases are involved in detoxification, stabilization of extracellular matrices and insect immunity, mediating the nitration of Anopheles midgut cells that are undergoing apoptosis in response to Plasmodium invasion [30].
Cellulose nitrate-acetate mixed esters (CNA) were synthesized by nitration of cellulose diacetate, using HNO3/H2SO4 as nitration agent.
Peroxynitrite is a highly reactive oxidant that mediates a variety of biological processes including inhibition of key metabolic enzymes, lipid peroxidation, nitration of the protein tyrosine residues, and reduction of cellular antioxidant defenses by oxidation of thiol pools [ 28].
Trinitrotoluene (TNT), a pale yellow, solid organic nitrogen compound used chiefly as an explosive, prepared by stepwise nitration of toluene.
To validate our proposal, six luminogens (Fig. 1d) were designed and synthesized through controlling nitration of TPA and TPE.
This ion frequently is the active agent in the nitration of organic compounds.
All synthetic silicates show high yields for nitration of arenes by using available nitro-source.
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