Sentence examples for mediates modifications in from inspiring English sources

Enhancer of zeste homolog 2 (EZH2), another important epigenetic regulatory factor, mediates modifications in histone methylation resulting in the repression of numerous tumor suppressor genes, such as DAB2IP, CDH1, and DKKI, as well as tumor suppressor microRNAs including miR-101, let-7c, and miR-200b.

The potential of targeting LOX and LOX-mediated matrix modifications in cancer treatment is schematized in Fig. 5.

Methylation of CpG dinucleotides within the promoter regions leads to the silencing of transcription process, mediated by modifications in the condensation status of the chromatin.

We detected 1975 and 2713 DEGs in grape flowers 1 h and 24 h following application with GA3, respectively, indicating that the alterations in grape inflorescence morphology noted following GA3 treatment are likely mediated through modifications in genomic expression profiles.

Since mitochondrial activities are developmentally regulated in the life cycle of trypanosomatids, Ufm1 mediated modifications of mitochondrial proteins may be important in such regulation.

This selection mechanism can be used in cI cassette-mediating modifications, such as the targeted insertion technique.

In addition, HOCl and Cl2 have been shown to mediate modifications of extracellular [ 56, 57] and intracellular components [ 40, 41].

In particular, in response to apoptotic induction, Che-1 is phosphorylated at threonine 144 (T144), and this modification is required for Pin1-mediated modifications and HDM2 ubiquitylation.

Our results demonstrate the efficient generation of genome modifications via the CRISPR RNA/Cas9 system in Drosophila and for the first time show germline transmission of Cas9-mediated modifications.

Beyond allelic differences, which can be mapped with QTL-analysis, welfare related biological responses may be mediated by acquired modifications in expression levels of genes and gene complexes.

TORC2 may also regulate cell growth, but importantly also appears to regulate cell morphology by mediating actin cytoskeletal modifications in response to growth factors.