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The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the toxic effects induced by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin
The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades.
Although weight loss certainly mediates many of the beneficial effects of exercise on type 2 diabetes risk reduction, exercise may also prevent or delay the onset of type 2 diabetes through independent mechanisms [22] involving insulin signaling, glucose and lipid oxidation, and reduced hepatic glucose production.
STAT-6 mediates many of the biological effects of IL-13 during asthma pathogenesis and fibrosis.
Insulin-like growth factor 1 (IGF1) mediates many of GH's physiological effects.
PAK is directly activated by Rac-1 and mediates many of its morphological effects in endothelial cells [ 33].
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Graphical user interfaces (GUIs) mediate many of our interactions with computers.
Of course, twentysomethings are not the only ones using social networking sites but, unlike older users, we have developed and mediated many of our friendships through them.
Insulin-like growth factor-I (IGF-I) is thought to mediate many of the beneficial outcomes of physical activity.
PIP3 mainly causes AKT to translocate to the plasma membrane, where it is activated by phosphorylation allowing it to mediate many of the biological consequences of PI3K activation.
However, as the responses in rats and humans differed, a further experiment was performed using C-AMP, a second messenger mediating many of the effects of a variety of hormones.
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