Sentence examples for mediates its proteolysis from inspiring English sources

We have mapped the essential region on BRCA1, which mediates its proteolysis in response to ionization.

We conclude that PSA is a strong suppressor of Aβ toxicity, mediating its rescue by clearance of the peptide, but achieving this without direct proteolysis.

In the context of t(4 11) leukemia, Taspase1 is a conditional oncoprotein because it mediates the proteolysis of the AF4 MLL fusion protein (p328).

Cyclin D1 associated with SKP1, CUL1 or CUL7, and CDK4, suggesting that its proteolysis is mediated by the SCF (SKP1-CUL1-F-box protein) or the SCF-like (SKP1-CUL7-FBXW8) complE3 of E3 ligases.

NS3-4A also mediates TRIF proteolysis, suggesting multiple functions for this protease.

Previous studies suggest that CCS52A2 is an activator of APC/C, which mediates protein proteolysis during mitosis [ 30, 31, 34].

Recent findings suggest that KLK6 indirectly mediates proteolysis of α-syn by regulating the activation of an unidentified metalloprotease [ 57].

The regulation of cig2 represents a paradox: Transcription of the gene is on the one hand induced by pheromone, yet the same signal also mediates proteolysis of the Cig2 protein [ 32].

These data reinforce that calpain activation and vimentin are required for successful surface translocation of MT1-MMP, which mediates extracellular matrix proteolysis during endothelial sprouting events.

These results indicate that arthritis increases serum IGFBP-3 by increasing its synthesis in the kidney and decreasing its proteolysis in serum and that these effects are not mediated by NO.

The central question of this work is whether ER stress alters secretase mediated APP proteolysis.