Under physiologic circumstances, LBP binds Gram-negative bacteria via the lipid A part of LPS [ 14, 15], which mediates its binding to the CD14 cellular receptor molecule presented by monocytes and macrophages.
However, since TNF mediates unique physiologic functions, in particular those related to host defense, TNF blockade may result in unwanted consequences.
Progesterone receptor (PR) mediates the physiologic effects of progesterone.
However, when uric acid exceeds its physiologic levels in the plasma, it can propagate oxidative damage.
It is now widely recognized that various cellular stimuli mediate their physiologic effects by the induction of complex intracellular signaling cascades, which culminate in the activation or induction of a particular gene or subset of genes.
Its physiologic role is still not fully established.
Its physiologic role is uncertain, as is its cellular mechanism of action.
Additionally, Pv-aCO2/Ca-vO2 was poorly correlated with respiratory quotient, and its physiologic behavior was different.
Dietary Br deficiency is lethal in Drosophila, whereas Br replenishment restores viability, demonstrating its physiologic requirement.
However, its physiologic response is not fully understood, and there is no consensus on H-reflex responses to spinal manipulation.
