Sentence examples for mediates its interaction from inspiring English sources
FAF1 is a 74-kDa protein with an N-terminal domain that mediates its interaction with Fas, the Fas-interacting domain (FID), and a functional ubiquitin-like C-terminal domain that is required for its pro-apoptotic activity.
Beclin-1 was recently identified as a novel Bcl-2 homology domain-3 (BH3 -only memBH3 -onlye B-cell lymember-2 (Bcl-2) family; it pofsesses a Bcl-2 homology-3 (BH3) domain thet mediates its interaction with the antiapoptotic proteins B-celland Bclymphoma-2ll lymphoma extra long).
To identify the domain(s) on HDAC6 that mediates its interaction with CLIP-170, plasmids that express various truncated forms of HDAC6 were transfected together with GFP-CLIP-170.
The SH3 domain of CAS mediates its interaction with several proteins involved in signaling pathways such as focal adhesion kinase (FAK), tyrosine phosphatases PTP1B and PTP-PEST, and the guanine nucleotide exchange factor C3G.
It is now established that the specificity in signaling of signal transducer and activator of transcription 3 (STAT3) is mediated by the SH2 domain of STAT3, which mediates its interaction with the phosphopeptide docking sites displayed by receptors and JAKs, dimerization and subsequent DNA binding.
These results indicate that the LIM1 domain of PINCH1 mediates its interaction with WT1 (Figure 6B).
Our finding is consistent with previous findings that the C-terminus of HDAC1 mediates its interactions with cofactors [49] and mutation of the HDAC1 sumoylation sites does not disrupt cofactor binding [37].
NRas comprises a G-domain and a hyper variable region (HVR, Fig. 1) that mediates its interactions with lipid bilayers.
Interestingly, 10 of the 13 amino acids of the binding cleft of Mdm2 that mediates its interactions with WT p53 are conserved in Mdm4 and yet nutlin does not potently inhibit the p53 Mdm4 interaction.
Alternatively, it may be a "scaffolding" protein important during mycofactocin biosynthesis but not after, or a carrier protein, analogous to apocytochrome c, that binds the mature product and mediates its interactions with other proteins.
If Sir2 is not sumoylated, it is presumable that some sumoylated proteins may mediate its interaction with other proteins such as Esc2 and regulate its activity.
