Sentence examples for mediates its induction from inspiring English sources
In summary, GYS1 contains an evolutionarily conserved HRE located at -314 that mediates its induction by hypoxia.
It has been shown that ATO mediates its cytotoxic effect by induction of apoptosis via disruption of mitochondrial transmembrane potentials and caspase-3 activation in various cell lines and human lymphocytes [ 18, 28].
In hepatocytes, TGF- β mediates its apoptotic function via induction of ROS and also of the proapoptotic protein BIM and thereby inducing the mitochondrial cell death pathway.
Preliminary mechanistic studies indicated that the antiproliferative efficacy of 15k was mediated by its induction of apoptosis, loss of mitochondrial membrane potential and cell cycle arrest at the sub-G1 phase.
Prior studies have proposed that the growth inhibition function of AR signalling in normal prostatic luminal cells is mediated by its induction of CDKN1B expression [ 30].
The protection against metastases by p53 may be mediated by its induction of anti-angiogenesis genes, but these characteristics of p53 have not been fully explored in the transgenic/knockout mouse models to date.
FGF21 may mediate its anti-atherosclerotic effects via induction of adiponectin in adipocytes and suppression of cholesterol synthesis in hepatocytes [ 29].
SAM has been shown to mediate its effect on sporulation through induction of bldK expression [ 47], in addition to other ABC transporters involved in development [ 48], and possibly through modulation of bldA expression [ 46].
Estrogens are potent mitogens that mediate its proliferative action through the induction of cyclin D1, the major regulator of entry into the G1 stage of the cell cycle, and promote the secretion of positive or negative paracrine growth signals by breast stroma cells, stimulating epithelial cells to proliferate [ 2, 3].
Growing recognition of a role for BAG3 in cancer suggests that its induction mediated by HNE or other electrophiles derived from oxidative stress may facilitate or promote tumorigenesis.
IFN-γ mediates the induction of CXCL10 and its binding to CXCR3 recruits CXCR3+ cells.
