Sentence examples for mediates its functions from inspiring English sources

Although ATX is a member of the nucleotide pyrophosphatase/phosphodiesterase family and had been proposed to mediate its activity as a nucleotide phosphodiesterase, it is now established that ATX mediates its functions primarily through production and action of LPA.

Insulin mediates its functions via IRS (insulin receptor substrate)–PI3K-dependent pathway [ 24].

Estrogen mediates its functions through two specific intracellular receptors, the ERα and the ERβ, which act as hormone-dependent transcriptional regulators [ 10, 11].

Estrogen mediates its functions through two specific intracellular receptors, estrogen receptor alpha and estrogen receptor beta, which act as hormone-dependent transcriptional regulators [ 25, 26].

NT mediates its functions through its two G protein coupled receptors: neurotensin receptor 1 (NTR1) and neurotensin receptor 2 (NTR2) (high and low affinity receptors, resp).

C/EBP α mediates its functions by binding to promoters of its target genes and interacting with agonist (co-activators) and antagonist (repressor) proteins in a cell-type-specific manner.

79, 80 Interestingly, CD36 has four palmitoylation sites on both N- and C-termini, and it was shown that palmitoylation plays a crucial role in targeting CD36 to lipid rafts, where it mediates its function.

IL18 is another proinflammatory cytokine that shares many biological, structural and functional properties with IL1 [ 20] and mediates its function through its receptor IL18R (IL18R1 and IL18RAP).

It has been proposed that HLA-DM mediates its function by shifting the equilibrium of peptide averse to a peptide receptive state; however, the peptide loading process is still relatively undefined [14], [15].

IL-4 mediates its function by binding to receptors expressed on target cells such as T lymphocytes, and macrophages.

Metastin has been identified as a metastasis suppressor gene product that mediates its function through a G protein coupled receptor, GPR54.