Sentence examples for mediates initiation of from inspiring English sources

This microglia activation is associated with p38-MAPK signaling and probably mediates initiation of hyperalgesia.

Phosphorylation of 4EBP1 leads to its dissociation from eIF4E, which mediates initiation of mRNAs translation [ 2].

Current data suggest that genomic instability is the most likely mechanism of action that mediates initiation of Tp53 R270H-driven breast carcinomas (Wijnhoven et al., 2005), whereas GOF activity is important in the initiation of Tp53 R270H-driven lung carcinomas (Olive et al., 2004).

However, the number of lung metastases was reduced significantly when this model of cancer was studied in the context of POSTN-null mice compared with wild-type control mice, suggesting that POSTN mediates initiation of metastatic lesions in the lung (Malanchi et al, 2012).

Selection of organelles for turnover via autophagy occurs at the organelle level with most possessing specialized, specific pathways to mediate initiation of degradation.

The combined data infer that the Tp53 R270H mutation (equivalent to the human Tp53 R273hotspotot mutation) can mediate initiation of CaP, at least in the context of Nkx3.1 haploinsufficiency and on a congenic FVB/NJ strain background.

As the undifferentiated ectoderm predominantly expresses TAp63 to mediate initiation of the stratification program, it can be inferred that the knockout of TAp63 in the prenatal stage leads to developmental failure-associated premature aging.

A recent study reported that the CCR6-CCL20 axis plays an essential role in controlling the entry of TH17 cells into the CNS and thus mediates the initiation of EAE [44].

Arp2/3 complex (one of the ARPs) mediates the initiation of new branches on pre-existing filaments.

Tissue factor (TF) is a protein that mediates the initiation of the coagulation cascade.

Unfortunately, the molecular mechanisms by which EMT mediates the initiation of breast cancer metastasis remain poorly understood.