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We found that Nod2 mediates induction of pro-IL-1β, TNF-α, IL-6, IFN-α and CXCL10 in response to B. burgdorferi in BMDM in vitro.
These data, in conjunction with the histological findings of an increase in crypt regeneration and improved intestinal restitution after WBI in mice treated with AdRspo1, as compared to AdLacZ, indicates that Rspo1 mediates induction of an intestinal regenerative process, possibly as a salvage mechanism, following exposure to WBI.
Our group previously reported that PSK mediates induction of the NKL cell proliferation and activation.
NF-κB is a transcription factor that mediates induction of genes by TNF in many cell types, including OCPs [ 38].
This observation is consistent with the hypothesis that LPS mediates induction of TTP through the production of TNF.
In our previous report [ 4], we showed that p53 mediates induction of autophagy after MMR processing of 6-TG.
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Additionally, we showed that PD-1 was necessary for DC-mediated induction of regulatory T cells.
We also discuss our current understanding of the molecular mechanism behind Xist RNA-mediated induction of the repressive epigenetic landscape at the Xi.
PALS1 knockdown led to a significant decrease in TCR-mediated induction of the activation markers CD69 and CD25 on cell surface (Figure 2A, B).
Western blot analysis indicated that heat shock mediated induction of endogenous Hsp90 expression was not inhibited in GFP positive tadpoles (Fig. 4C).
p75NTR stimulates calpain activation through its Chopper cell death domain, [11] and mediates NGF-induced inhibition of GSK-3β [12]; in addition, it can mediate induction of cell death through the activation of JNK [13].
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mediates internalization of
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mediates fusion of
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mediates adhesion of
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mediates regulation of
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mediates endocytosis of
mediates upregulation of
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