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In rat submandibular gland (SMG), the P2Y1 receptor (P2Y1R) mediates increases in the intracellular calcium concentration, [Ca2+]i that diminish as the animal ages from 1 to 4 6 weeks.
Plasma glucose concentration is an important factor in this response and mediates increases in glucose-induced islet β-cell growth and proliferation [1], [2], [3], [4].
Pharmacological studies suggest that cholinergic neurotransmission mediates increases in attentional effort in response to high processing load during attention demanding tasks [1].
We further show that AKAP12β associates with PKA and mediates increases in activity of at least one downstream target of PKA.
These findings suggest that relaxin mediates increases in renal function in humans.
These actions of ANP are mediated by a membrane-bound guanylyl cyclase (GC) receptor, GC-A, which mediates increases in intracellular cyclic GMP levels in response to ANP binding [ 25, 26].
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Decreases in 5-HT levels that occur during REMSD likely mediate increases in avoidance responding.
Possible mechanisms underlying biochar mediated increases in soil Mn solubility and decreases in corn Mn uptake were discussed.
Furthermore, we identify potential AMPK transcription factor targets that mediate increases in PGC-1α transcription in muscle.
At the same time, there is emerging evidence that stresses other than hypoxia may mediate increases in genes that are normally considered hypoxia responsive.
These data suggest that IGF axis mediated increases in lifespan due to daf-2 remain active in the presence of adr-1 and adr-2 background genotypes, but with less potency than in a N2 wild type background.
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