Sentence examples for mediates expression of from inspiring English sources
NF-κB activation mediates expression of inflammatory genes, in term induces cell apoptosis.
Apart from its stimulatory effect on LEE, grlA also mediates expression of non-LEE encoded effectors [25].
CREB mediates expression of a high number of genes that are implicated in a wide array of cell functions, including transcription, cell cycle, and immune regulation [41], [50].
The TCF/LEF-1 family (TCF-1,-3, -4 and LEF-1) mediates expression of Wnt target genes by acting as a repressor or activator of Wnt target genes [9], [10].
In addition, up-regulation of miR-31 mediates expression of the non-canonical ligand Wnt5a, which induces epithelial-to-mesenchymal transition (EMT), and dramatically enhances the malignant phenotype of lung cancer cells (Ripley et al, submitted for publication).
In addition these results suggest that there is a negative feedback loop in which TNFα-induced NF-κB activity mediates expression of optineurin, which itself functions as a negative regulator of NF-κB.
Overall, Pten can be directly linked to the extrinsic apoptotic pathway through mediation of TNFα signaling and the intrinsic apoptotic pathway by mediating expression of mitochondrial apoptosis factors.
Integrin β1 was shown to mediate expression of FAK in lung cancer cells, with proliferation following metastasis dependent on β1 and FAK expression levels [44].
Moreover, RIM1 confers sustained activity and neurotransmitter vesicle anchoring to pre-synaptic Ca2+ channels [50], which mediate expression of pre-synaptic LTP [51].
Infecting Müller glia, a cell that is accessible from the vitreous and transverses the entire thickness of the retina, would be ideal to mediate expression of secreted neurotrophic or anti-angiogenic factors throughout all layers of the retina (Fig. 1).
To overcome these issues, we describe here a Cre-transgenic line that can mediate expression of multiple Cre-dependent transgenes of choice in very few neurons of the adolescent neocortex, hippocampus, olfactory bulb, striatum, amygdala, hypothalamus and superior colliculus.
