Sentence examples for mediates cell cycle from inspiring English sources

These results provide evidence suggesting that NFκB mediates cell cycle progression and demonstrates a mechanism linking increased NFκB activity with GBM cell growth and cell cycle disregulation.

p53 mediates cell cycle arrest or apoptosis in response to DNA damage.

The IMPDH inhibitor MPA has been shown to activate and stabilize p53, which in turn mediates cell cycle arrest and apoptosis in response to guanine nucleotide depletion [30] [32].

ATM kinase also mediates cell cycle checkpoints and DSB repair by HR or NHEJ, depending on the DSB end structure and on the cell cycle at the time of damage [13], [14].

Nonmutated p53 normally responds to radiation with a high level of expression and subsequently mediates cell cycle arrest and DNA repair activation [ 51].

We further conclude that Sorafenib similarly mediates cell cycle arrest in malignant and non-malignant cells such as regenerating healthy hepatocytes via identical mechanisms.

Unlike deletion of apoptosis genes, genes that mediate cell cycle exit by differentiation are present in myelodysplastic syndrome (MDS) and AML cells but are epigenetically repressed: MDS/AML cells express high levels of key lineage-specifying transcription factors.

Regarding the adult liver-enriched miRNAs, similar to let-7, miR-23b is capable of inhibiting cell proliferation [44], and may mediate cell cycle arrest in mature hepatocytes.

At the IRIF, BRCA1/BARD1 in turn attracts other proteins such as Rad51 and BRCA2 that mediate cell cycle checkpoints and DNA repair (reviewed recently in [2], [8], [10]).

To confirm that Lmna−/−-siGank have insufficient pRB function to mediate cell cycle arrest, GFP-p16ink4a was introduced and BrdU incorporation was monitored.

Inactivation of AKT results in dephosphorylation and activation of FOXO transcription factors, reported to mediate cell cycle arrest, DNA repair, and apoptosis [13], [14].