Jalalvand, F. et al. Haemophilus influenzae protein F mediates binding to laminin and human pulmonary epithelial cells.
The Erh1 binding pocket that mediates binding to Mmi1Trp112 was also nearly identical between S. pombe Erh1 and human ERH (Supplementary Fig. 3b, c).
Host specificity and mutagenesis studies suggest that the helix D region of CD81 mediates binding to HCV-E2.
Previously, mechanical unfolding of fibronectin has been modeled by applying tensile forces at the N- and C-termini of fibronectin domains; however, physiological loading is likely focused on the solvent-exposed RGD loop in the 10th type-III repeat of fibronectin (10FNIII), which mediates binding to cell-surface integrin receptors.
Cpl-1 has a C-terminal domain that mediates binding to choline in the cell wall for adequate positioning of the N-terminal catalytic domain to cleave its substrate (Diaz et al., 1990; Perez-Dorado et al., 2007).
Recently it was shown that Cyt2Aa specificity could be modified to kill aphids by the insertion of a peptide sequence, in exposed loop regions, that mediates binding to an aphid APN (Chougule et al. 2012).
Hemagglutinin, a membrane glycoprotein of the influenza virus mediates binding to sialic acid on target cells and is a fusion-inducing component, facilitating antigen delivery to immunocompetent cells.
Nuclear localization of large proteins, such as LANA, requires a nuclear localization signal (NLS) that mediates binding to members of the karyopherin family of nuclear transport proteins.
The high affinity binding site mediates binding to the homodimer EPO receptor and is responsible for the haematopoietic response, while the low affinity binding site mediates binding to the EPO receptor - common β receptor heterotrimer complex, a interaction, which has been proposed to be responsible for the pleiotropic effects of EPO [30].
Botulinum neurotoxin structure consists of light chain (LC) - the protease domain responsible for enzymatic cleavage of SNARE proteins, and heavy chain (HC) whose receptor domain which mediates binding to membrane receptor and translocation domain mediates toxin translocation into neurons.
The catalytic center of PTEN is localized within its N-terminal domain, whereas the C-terminal C2 domain mediates binding to phospholipids and recruitment to cellular membranes [27], [28].
