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The major target of immunity is EBV glycoprotein 350/220 (gp350) that mediates attachment to B cells through complement receptor 2 (CR2/CD21).
Background & Aims: Integrin αvβ6 is highly expressed on certain activated epithelia, where it mediates attachment to fibronectin and serves as coreceptor for the activation of latent transforming growth factor (TGF -β1.
The Haemophilus influenzae HMW1 protein is a high-molecular weight non-pilus adhesin that mediates attachment to human epithelial cells, an essential step in the pathogenesis of H. influenzae disease [1] [3].
The H protein mediates attachment to either one of these cell surface receptors, and signals to the F protein to trigger membrane fusion.
Binding of the ligand mediates attachment to the matrix, while phosphorylation of the receptor relays spreading of the cells to the matrix [ 27] through the formation of filopodia, lamellipodia, and stress fibers [ 28].
24 The fimF encodes the adaptor component of a mannose-sensitive type I fimbria encoded by the fim gene cluster, which is well conserved among Salmonella serotypes and mediates attachment to epithelial cells.
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Cadherins are components of the adherens junction (AJ), and they span the cell membrane to mediate attachment to adjacent cells.
The pilus-associated adhesin PilC1 plays a critical role in mediating attachment to host epithelial target cells [22], [23].
The bacterial surface provides the first barrier against innate immune mechanisms as well as mediating attachment to cells/surfaces to resist clearance.
Moreover, the dorsal and ventral haltere surfaces remain separate throughout development, with integrins mediating attachment to the central haltere matrix rather than dorsal cells.
Flagellum-mediate attachment to substrate is the first step in the initiation of biofilm formation [32], a mode of growth which is known to contribute to the resistance of bacteria to antibiotics and other antimicrobial agents [34], [35].
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