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Here, I show that SRF mediates a response to zymosan stimulation in primary macrophages.
These results strongly suggests that Vinculin indeed mediates a response of the E-cadherin complex to actomyosin-based force that results in more efficient epithelial barrier formation.
In Caenorhabditis elegans the UNC-40 (DCC) receptor mediates a response to the UNC-6 (netrin) guidance cue that directs HSN axon development.
This result indicates that the 1UP1.4 region contains a conserved Hox/Pbx regulatory element that mediates a response to group 1 Hox proteins.
Other genes that were significantly up-regulated in our study include several interferon-stimulated genes (ISGs) and the urokinase plasminogen activator (PLAU), which mediates a response to the inflammation induced by the virus.
Both probiotics and vitamin C are known to modulate the immune system, and the combination probably mediates a response through immune-modulation although the absence of any significant changes in cytokines levels between the active and placebo groups in our study may suggest the existence of an alternate mechanism.
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However, it appears that each of the mechanisms may mediate a response to particular signals.
Thus HAEC express components of the Hh pathway that are known to mediate a response to Hh ligands.
Subsequently, the pharmacological actions of trace amines led Burn and Rand (1958) to propose that they mediated the release of endogenous neuronal noradrenaline into the synaptic cleft, where it acted upon postsynaptic autologous receptors to mediate a response.
For example, natural killer (NK) cells produce long-lived cell populations after exposure to a pathogen, which clonally expand upon secondary challenge and mediate a response that results in specific, increased protection compared with naive NK cells [ 17, 18].
Under high ABA concentrations, these PP2C proteins are inactivated by PYR/PYL/RCAR, allowing for the phosphorylation of SUCROSE NONFERMENTING1-RELATED PROTEIN KINASE2 (SnRK2) family members, which phosphorylate downstream ABA signaling components to mediate a response (Nakashima et al. 2009).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com