Sentence examples for mediates a negative from inspiring English sources
Upon MHC class I engagement LIR-1 mediates a negative signal by its immune receptor tyrosine-based inhibitory motifs in the intracellular domain [30], [31].
I-Smad mediates a negative feedback by sequestering the active receptor (5 and 6) and can be degraded (19).
DESeq mediates a negative binomial distribution by modeling the biological and technical variance for testing DE genes in two experimental conditions.
The increased GUS expression in A. thaliana plants transformed with a promoter GUS fusion where the 21 bp motif has been deleted (Fig. 4) indicates that the motif mediates a negative regulation.
SOCS mediates a negative feedback mechanism in LPS induced TLR4 transduction, possibly acting downstream in MyD88 dependent pathway, at IRAK and p50/p65 levels, in order to reduce the production of proinflammatory cytokines [ 30].
Conversely, the genetic inhibition of autophagy-relevant proteins such as Beclin 1 (ATG7), and7 ATG12TG12 reportedly mediates a negative effect on the healthy lifespan of model organisms including Caenorhabditis elegans [ 23].
These stimulatory effects of BMPRII and ACTRIIB mutation were consistent with the results obtained from transient gene expression experiments in the absence of BMP7 suggesting that wild type BMPRII as well as ACTRIIB receptors were involved in mediating a negative regulation of telomerase activity.
A number of recent reports show that Ser/Thr kinases mTOR, JNK, and PKCζ mediate a negative feedback loop in the insulin signaling cascade by phosphorylating IRS-1 at Ser position 307 [29], [29].
The elevated intracellular pyruvate level mediated a negative control over the malic enzyme (-1.1).
Together, these data suggest that miR-308 is sufficient to mediate a negative regulatory mechanism controlling dMyc in vivo.
Membrane bound CTLA-4 acts by interfering with CD28/CD80-CD86 interactions by competitive binding and also by mediating a negative signal interfering with T cell receptor stimulation [ 9].
