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Altogether, populations of these mountain ranges may have been mediated with different levels of historical gene flow during the glacial maxima.
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As a scaffold protein, Rabaptin-5 comprises several coiled-coil regions which can mediate interactions with different proteins to exert different functions.
Results obtained with the cnidarian HoxE protein confirm the important role of a long disordered region in mediating interactions with different TFs.
Supporting this hypothesis is the recent demonstration that the domains encoded by the mutually exclusive α1/α2 exons of mouse MEF2D can mediate interactions with different sets of co-repressors or co-activators [23].
However, the perceptual experience mediated with a substitution device might be different from perceiving with the corresponding natural organ and therefore giving rise to transformed and extended perceptual capacities (Auvray & Myin, 2009).
Alternatively, perhaps within one nutritional strategy, potential benefits were counter balanced by harms, with each mediated by different mechanisms associated with the strategy.
CCN proteins have been suggested as potent angiogenic modulators, with activity mediated by interactions with different integrins and growth factors [ 41].
The regulation of high oxidative gene expression by PGC-1 is mediated by interactions with different isoforms of a family of nuclear hormone receptors, the peroxisome proliferator-activated receptors (PPARs) (Gilde and Van Bilsen 2003).
As a scaffold protein, Rabaptin5 comprises several coiled-coil regions that mediate interactions with different proteins to exert different functions.
Extended disordered regions in ATP-independent chaperones such as the small heat shock proteins (sHsp) mediate interactions with different substrates.
Our results revealed that co-treatment with erlotinib and MPT0E028 synergistically increased the levels of apoptotic proteins in TKI-resistant PC9/IR and CL97 cells (in which resistance is mediated by different mechanisms) when compared with cells treated with either agent alone.
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