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We identified 214 genes that correlate with leptin mediated weight loss.
The present study was designed to identify hepatic genes and pathways correlated with leptin mediated weight loss.
Next, we performed cluster analyses on the 214 genes significantly correlated with leptin mediated weight loss and found 4 clusters, each of which defined a unique pattern of expression (Figure 3).
Change in restraint and disinhibition mediated weight change.
However, the underlying mechanisms for GLP-1 mediated weight loss remain poorly understood and may involve direct, GLP-1R mediated, and indirect, e.g. neuronal, pathways [ 32].
Change in restraint and disinhibition (variables associated with eating behavior) mediated weight change.
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Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.
Mitochondrial metabolic pathways are major regulators of leptin-mediated weight loss.
We found 214 genes significantly correlated with leptin-mediated weight loss.
The purpose of this study was to identify genes and subsequent pathways correlated with leptin-mediated weight loss.
In conclusion, this study identified key molecular pathways and downstream target genes involved in the leptin-mediated weight loss.
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