Sentence examples for mediated virus entry from inspiring English sources

In an effort to directly demonstrate that airway protease mediated virus entry enhancement is due to the presence of cleavage site on the SARS spike glycoprotein, 16HBE cells were pre-incubated with wild-type (SARS-CoVpp) or mutant (R667App) pseudotypes on ice, which allowed virus attachment but not entry.

We also note that hCCR5 staining with antibody did not correlate well with the efficiency of hCCR5 mediated virus entry.

Our results showed that both the wild-type and mutant spike glycoproteins were functional and mediated virus entry into 16HBE cells (Figure 5A and 5B).

We postulate that receptor-bound spike glycoprotein is required for cleavage mediated virus entry enhancement, as the spike glycoprotein undergoes conformational changes once it binds to the cellular receptor.

We reported previously that a small molecule named CL-385319 could inhibit H5N1 influenza virus infection by targeting hemagglutinin, the envelope protein mediating virus entry.

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity.

In vitro studies have suggested that the envelope glycoprotein (GP1,2) of EBOV mediating virus entry may also directly contribute to the viral pathogenesis, as cell surface expression of GP1,2 can induce adherent cell rounding and detachment and sterically mask some cell surface molecules, such as β1-integrin (reviewed in Ning et al., 2017).

Hwang et al. (2012) reported antiviral aptamers that may bind to virus glycoproteins responsible for mediating virus entry into the cell [ 20].

These viral factors act in concert with host proteins to mediate virus entry and to coordinate RNA replication and virus production which is coupled to lipoprotein biogenesis.

ORF2 peptide-binding experiments suggested that the C-terminal region of ORF2 may mediate virus entry by binding to heat shock cognate protein 70 (HSC70) on the cell surface.

The H5N1 virus was also shown to infect nasopharyngeal and oropharyngeal epithelia, which do not express SAα-2,3Gal, suggesting that other binding sites on nasopharyngeal and oropharyngeal epithelia may be able to mediate virus entry.