The Spike (S) glycoprotein of coronaviruses (CoV) mediates viral entry into host cells.
Influenza virus surface glycoprotein, hemagglutinin, holds a critical role in mediating viral entry into host cell.
The Spike (S) protein of SARS-coronavirus (SARS-CoV) mediates viral entry into host cells.
The genome encodes seven structural proteins, one of which is glycoprotein, a surface protein that plays a fundamental role in mediating viral entry into host cells.
All Ab therapeutics currently under development for Ebola virus disease target the ebolavirus surface glycoprotein, GP, which mediates viral entry into host cells by catalyzing viral membrane fusion in host cell endosomes1,2,5.
The viral "spike" of HCV is formed by two envelope glycoproteins, E1 and E2, which together mediate viral entry by engaging host receptors and undergoing conformational changes to facilitate membrane fusion.
Although the infection routes of these viruses within the bodies of insect vectors are well established, cellular receptors on the microvilli, intercellular junctions, and basal lamina for mediating viral entry or spread in insect gut epithelium have not been well identified or characterized.
The HIV-1 co-receptor CCR5 possesses sulfo-tyrosine (TYS) residues at its N-terminus (Nt) that are required for binding HIV-1 gp120 and mediating viral entry.
This is important in context of cellular entry of virus because PS is exposed on the membranes of various enveloped viruses and is known to play an important role in mediating viral entry (Mercer and Helenius, 2008; Soares et al., 2008).
The cellular receptor of each ALV subgroup is encoded by a tumor virus locus (TV), which mediates viral entry.
