Sentence examples for mediated via two from inspiring English sources

VEGF actions are mediated via two major receptors, Flt-1 and KDR, and hence the expression of these receptors was investigated.

These three effects could in turn be mediated via two types of Ly49-MHC class I interactions: cis or trans.

These results indicate that butyrate transport is mediated via two distinguished transporters at the luminal and basolateral poles.

PDGFs exist mainly as homodimers (PDGF-AA, -BB, -CC, and -DD), and their cellular responses are mediated via two tyrosine kinase receptors (PDGFR-α and PDGFR-β) [ 53].

Nevertheless, it is unknown, whether this depends on direct protein interaction between the two IκBs or whether it is mediated via two different κB binding sites, or via two different dimers, which are sequentially exchanged.

However, although estrogenic responses are mediated via two subtypes of ERα and ERβ, which differ in their ligand binding ability and transactivation properties (Kuiper et al. 1997; McInerney et al. 1998), the estrogenicity of PBDEs has been evaluated on the basis of their effects via ERα, but not via ERβ.

The biological function of prostaglandin E2 (PGE2) is mediated via four G-protein-coupled receptors EP1 EP4 (Sugimoto and Narumiya, 2007).

Our data suggested that cafestol could induce ABT-737-mediated apoptosis via two mechanisms; downregulation of Mcl-1 expression and upregulation of Bim expression.

Cellular adiponectin responses are mediated via the seven transmembrane domain type 1 and type 2 adiponectin receptors as well as T-cadherin [ 17].

Interestingly, Erk1/2 might positively regulate FcεRI-mediated MC degranulation via two different pathways.

In the NPM ALK fusion protein, oligomerization mediated via NPM juxtaposes two ALK tyrosine kinase domains, resulting in autophosphorylation and activation of ALK kinase activity [ 115, 116].