Sentence examples for mediated via phosphorylation from inspiring English sources

Activation of AP-1 under oxidative conditions is believed to be mediated via phosphorylation of protooncogene c-jun [ 68].

This effect is mediated via phosphorylation of cofilin, which then becomes inactive and thus unable to severe actin filaments that would be needed to extend the actin-cytoskeleton.

Regulation of SAF-1 activity is mediated via phosphorylation of this protein by various protein kinases, which markedly increase its DNA-binding activity 21– 21.

In the present study we have demonstrated that endogenous LRRK2 interacts with endogenous 14-3-3 14-3-3 14-3-3rms and that this binding is mediated via proteinrylatisoformsRRK2 andSer and Ser.

In yeast, this recruitment is mediated via phosphorylation of the kinetochore protein Spc105/Knl1 by Mps1, which enhances binding of Bub1 to Knl1 (London et al. 2012; Shepperd et al. 2012; Yamagishi et al. 2012).

Taken together, these studies provide evidence that JNK helps to mediate the TPA-induced cell growth arrest and apoptosis in LNCaP human prostate cancer cells; and this effect might be mediated via phosphorylation of c-Jun.

There are no experiments demonstrating that the translation control observed in response to the arsenite treatment is mediated via eIF2 phosphorylation.

Hypoxia has been shown to regulate SCF expression in vitro and addition of SCF reduces caspase 3-mediated apoptosis via phosphorylation of Bad.

Whilst our data revealed no Bcl-2 modifications in these murine P388 leukaemia cells after exposure to either vinflunine or to taxol, similar treatments of human CEM leukaemia cells clearly resulted in Bcl-2 phosphorylation, suggesting that the apoptotic signal triggered by vinflunine in these P388 cells is not mediated via Bcl-2 phosphorylation.

On the other hand, both Akt and SGK1 are involved in insulin-mediated ROMK inhibition via phosphorylation of WNK1.

have shown that global metabolic rate suppression, mediated via reversible protein phosphorylation (RPP), is crucial for survival [3].