This work provides the first account of 'kinase-mediated trapping' of cancer therapeutics.
Liu, Q. et al. Nanoparticle-mediated trapping of wnt family member 5A in tumor microenvironments enhances immunotherapy for B-Raf proto-oncogene mutant melanoma.
It is interesting to note that lipid-mediated "trapping" of RhoB into MVB is selective since Rab7, which is also associated with the late endosome limiting membrane, is not accumulated in this compartment.
It is thought that AChRs diffusing freely on the muscle surface become clustered at traps generated by synaptogenic stimuli at the NMJ [15]; this diffusion-mediated trapping of AChRs has recently been directly visualized through single-molecular tracking with quantum dots [16], [17].
The increased reliance on RNase H2 incisions may be caused by SOD1G93A-mediated trapping of redundant enzymes involved in ribonucleotide incision and removal such as topoisomerase 1 (Top1) (42).
The non-radiative dynamics can be explained by Auger-mediated trapping of holes and the lifetimes of this process calculated by an atomistic model are in agreement with experimental values if assuming surface oxidation of the CQDs.
Recent work has shown that the Auger-mediated trapping (AMT) of holes can be used to explain the charge dynamics observed in a number of CQD types, including CdSe and InAs/ZnSe CQDs.[ 26] An atomistic model of a CdTe CQD has been developed and is used to calculate AMT rates for holes, and the results are compared to the non-radiative lifetimes found experimentally.
Expression of the marker gene in transduced cells leads to enzyme-mediated trapping and accumulation of a specific substrate in the cell or by receptor-mediated specific binding on the cell surface.
The physical mechanisms underlying trapping by optical means are dictated by the optical properties of the particles and the surrounding medium, as well as the physical nature of the light-mediated trapping forces.
Also, the efficiency of gene isolation after reporter expression-mediated trapping should be optimized in such a selected sub-population.
Proposed mechanisms underlying the adipocyte-mediated glucose-lowering action of TZDs are the trapping of fatty acids inside adipocytes and away from muscle, the so-called 'fatty acid steal' hypothesis and the altering adipokine release [ 1].
