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This has been proposed to occur by various mechanisms including taxane-mediated induction of AR transcriptional corepressors and prevention of microtubule-mediated transit of AR to the nucleus.
Lipid-mediated transfections (TransIT-mRNA, Mirus) were performed according to the manufacturer's instructions.
Another possibility is that inter-Golgi transport of anterograde cargo is mediated via indirect transit through the endosomal pathway.
For example, fewer breast cancer cells that stably express BRMS1 reached lungs or bone compared to controls, suggesting BRMS1-mediated cell death during transit most likely via anoikis (Hedley et al, 2008).
Notably, MGL deficiency caused complete insensitivity to CB1 receptor agonist-mediated inhibition of whole gut transit and ileal contractility suggesting local desensitization of CB1 receptors.
infusion, agalsidase alfa is removed from the blood by mannose-6-phosphate-mediated cellular internalization and transits into the lysosomes.
State-mediated contract talks resumed today between the city transit authority and the union representing striking bus and rail operators, whose five-day walkout has left nearly half a million commuters searching for ways to get to work.
Large molecules and molecular complexes (>60 70 kDa) transit the pore through active carrier-mediated, signal-dependent processes [11].
Liposome-mediated drug delivery is rendered with inherent ability to transit across membrane barriers more efficiently.
First, it must be entrained in a pathway and survive transit, where a pathway is a human-mediated process that facilitates the movement of species from one region to another.
The addition of ligands such as polyethylene glycol (PEG) allow improved non-specific uptake by receptor-mediated endocytosis (RME) within tumors, as well as improved transit times in systemic circulation (Zhang et al. 2008; Kumar et al. 2013; Lechtman et al. 2013; Chithrani et al. 2006).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com