Sentence examples for mediated toxicity on from inspiring English sources

It seems likely that the downregulation of the hsp-16 family and ftn-1 contributes to the higher sensitivity to juglone in xpa-1 and nth-1, particularly as it is unlikely that a short acute exposure to oxidizing agents (or heat-stress) may lead to DNA-damage mediated toxicity on organismal level.

Overall, this work provides further insights into the impact of Aβ1-42-mediated toxicity on the temporal and spatial progression of subtle myelin disruption during the early presymptomatic stages of AD and may help to validate new therapeutic options designed to avert these early impairments.

Thus, depending on the expression of the full length or the cleaved fragment of mutant Htt, either D1R or D2R seem to be differentially involved in DA-mediated toxicity on striatal neurons.

This result indicates that CysC exerts a neuroprotective activity against mutant SOD1-mediated toxicity on primary cultured motor neurons as well as N2a cells.

To exclude the effects of pIpC-induced Cre-mediated toxicity on hematopoietic stem and progenitor cells (HSPCs), we compared the immunophenotypic and functional properties of HSPCs from Cited2+/+ Mx1-Cre and Cited2fl/fl mice and found no apparent differences.

In the early 1990s scientists began to synthesize information about the potential impacts of endocrine-mediated toxicity on humans and wildlife, arriving at the hypothesis that weakly endocrine-active compounds in the environment were having significant adverse effects on public and environmental health (Colborn and Clement 1992).

We observed that GKAs did not increase glucose uptake in endothelial cells and did not have pleiotropic actions to enhance glucose mediated toxicity and we identified several favourable actions most likely unrelated to actions on GK.

Tamoxifen/OHT-regulatable Cre fusion proteins demonstrate titratable toxicity, suggesting that Cre mediated toxicity is dose- and exposure time-dependent.

We previously identified by immunoprecipitation an aberrant and possibly harmful interaction between mutSOD1 and Bcl-2 in spinal cord mitochondria (7) and hypothesized that mutSOD1-mediated toxicity depends on this interaction.

Grades III-IV immune mediated toxicities specifically pneumonitis were observed in 14/296 patients [ 44].

Although there is a previous report indicating that AAP potentiates staurosporine-mediated toxicity in neuroblastoma [11], information on direct AAP neurotoxicity has not been described.