Sentence examples for mediated toxicity of from inspiring English sources

This highlights that the background diet is a critical variable in the risk assessment of POPs and warrants further investigation of dietary mediated toxicity of food contaminants.

Higher sensitivity of cancer cells toward ROS generation due to NPs exposure as compared to normal cells makes them more suitable to explore the potential mechanisms of ROS mediated toxicity of NPs.

The oxidative stress mediated toxicity of heavy metals involves damage primarily to liver (hepatotoxicity), central nervous system (neurotoxicity), DNA (genotoxicity), and kidney (nephrotoxicity) in animals and humans.

Finally, it has been argued that only chemicals that are dioxin-like in structure and lead to AhR-dependent acute toxicity (as opposed to CYP-mediated toxicity of PAHs) should be considered in toxic potency analyses (Van den Berg et al. 2006).

As shown in Supplementary Fig. 5, all three O1 El Tor pandemic isolates behaved similarly in our amoebal infection assay and confirmed the hemolysin-mediated toxicity of the hapA-minus variants.

However, target-mediated toxicity of β-secretase inhibition cannot be ruled out, as long as the major substrates of this enzyme are unknown.

Furthermore, our results also suggest that the dioxin-mediated toxicity of Ahr is not solely due to inducing its nuclear translocation or to changes in affinity for its dimerisation partners, but also entails an increase of the transcriptional regulatory activity of Ahr (Figure 5F).

These observations are discussed in terms of a possible model for the metabolism-mediated toxicity of MISO and the roles which sulphydryls and O2 may play.

In early experiments, Lorenzo et al. showed that aurintricarboxylic acid, an endonuclease inhibitor that stops apoptosis, is able to reduce amylin-mediated toxicity of islet cells [ 75].

Pentitin prevented NMDA-mediated toxicity of both mature and immature neurons, thus confirming a role of this secreted factor in part of the neuroprotection observed with NPC-CM [ 104].

However, we cannot exclude the possibility that AhR expression in fetal brains increases with gestational age, resulting in AhR-mediated toxicity of POPs in NPCs at later gestational stages.